Infrared detectors and imaging systems are becoming increasingly important in a diverse range of astronomic, military, and civilian applications. In recent years, this field has gained significant attention while incorporating various material combinations and architectures into detector designs with a strong focus on applicability into clinical domains. Here, we will discuss some of our detector structures, their results, and our latest work on disease detection. Our study of the biomedical application of infrared includes exploration of an Affordable, Sensitive, Specific, User-friendly, Rapid, Equipment-free, and Deliverable (ASSURED) diagnostic regimen and testing its clinical feasibility for inflammatory bowel diseases (IBDs) and cancer (Breast, Melanoma, and Lymphoma) screening. Our study using Fourier transform infrared (FTIR) spectroscopy in attenuated total reflectance (ATR) sampling mode, analyzed body fluids in order to identify reproducible, stable, and statistically significant differences in spectral signatures of the IR absorbance spectra between the control and disease samples. These results show that serum samples can be used to detect the biochemical changes induced by these diseases. This technology can be further developed into a futuristic, noninvasive, personalized diagnostic tool for various diseases in which patient-to-patient differences in molecular signatures would allow the assessment of disease status and personalized drug management. Speaker(s): Prof. Unil Perera, Room:MC603, McConnell Engineering building, 3480 University Street, H3A 0E9, Montreal, Quebec, Canada, Virtual: https://events.vtools.ieee.org/m/312234